Evidence supporting the use of: Vitamin B6 (pyridoxamine HCl)
For the health condition: Depression
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin B6 (pyridoxamine HCl), as well as other forms of vitamin B6, has some scientific basis for use in supporting or treating depression, although the evidence is limited and not robust. Vitamin B6 is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play a role in mood regulation. Several observational studies have found that individuals with low levels of vitamin B6 are more likely to experience depressive symptoms. Some small-scale clinical trials have explored vitamin B6 supplementation as an adjunct to standard antidepressant therapy or in populations with B6 deficiency showing modest improvements in mood. However, results are mixed, and large, well-designed randomized controlled trials are lacking.
A 2022 double-blind placebo-controlled study (Parry et al., 2022) found that high-dose vitamin B6 supplementation reduced self-reported anxiety but not depression scores in young adults. Earlier meta-analyses and reviews suggest a potential benefit for B-vitamin supplementation (including B6) in individuals with low baseline levels or elevated homocysteine, but little effect in the general population. Overall, while there is a plausible biochemical rationale and some clinical support, the strength of evidence is moderate to low, justifying a rating of 2. Vitamin B6 supplementation may be most useful in those with a demonstrated deficiency rather than as a general treatment for depression.
More about Vitamin B6 (pyridoxamine HCl)
More about Depression
Other ingredients used for Depression
5-Hydroxytryptophan (5-HTP)acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
tongkat ali
almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
whey protein
zinc
suma
gastrodia
mugwort
alpinia galangal
commiphora
blackboard tree
caesalpinia crista
peony
lingzhi
lemongrass
kanna
cistanche
dodder
morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
yerba mate
hypothalamus
cocoa
thyroid substance
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Arginine Creatine
Ardisia
Angelica
Apigenin
Albizia
Agmatine
Agarwood
Alpha lactalbumin
Asteracea
Algal protein
Aniracetam
Amor seco
Betony
Baikal Skullcap
Broussonetia
Beta-hydroxybutyrate
Biopterin
Butea monosperma
Beef liver
Bacopin
Brahmi
Bacopa
Bee products
bacoside
Baicalin
Black Hellebore
Biogenic amine
Camellia sinensis
Coconut
Caryophyllene
Common Monkey Flower
Crocin
Clary sage
Catalpol
Codonopsis
Curcuminoid
Citrus
Chinese Raisintree
Curcumen
Cymbopogon Martini
Centella asiatica
Chocolate
Creatine
Curcuma
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Folinic Acid
Folic Acid
Flavonoids
Fragrant Rosewood
Fish
Fatty acids
Frankincense
Guanidinoacetic acid
Ginsenosides
Griffonia simplicifolia
Glutamate
Glycine
Gastrodin
jasmine
Little ironweed
Milk Protein
Mimosa
Phenylethylamine (PEA)
Rose
Spikenard
Shellfish
Sandalwood
Sweet Orange alcohol
Vervain
walnut
yohimbine
Zucchini
Other health conditions supported by Vitamin B6 (pyridoxamine HCl)
AnemiaCarpal Tunnel Syndrome
Depression
Diabetes
Migraine
Nausea and Vomiting
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Stress
