Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (as pyridoxal 5'-phosphate, the active form) has some scientific basis for its use in supporting or treating depression, though the evidence is limited and not robust. Vitamin B6 is a cofactor in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play roles in mood regulation. Observational studies have reported associations between low vitamin B6 status and increased risk of depressive symptoms, especially in certain populations such as older adults. Some small clinical trials have examined B6 supplementation—alone or with other B vitamins (such as folic acid and B12)—in depression, with mixed results. While some studies suggest B6 may improve mood or reduce depressive symptoms, especially in those who are deficient, most high-quality randomized controlled trials have not found a clear benefit for the general population.

There is insufficient evidence to support B6 as a primary or sole treatment for depression. Current clinical guidelines do not recommend routine B6 supplementation for depression except in cases of documented deficiency. However, correcting a deficiency, if present, may help optimize neurotransmitter synthesis and potentially improve mood. Overall, while the biological rationale is plausible, direct evidence for efficacy is weak, and more rigorous research is needed.

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