Evidence supporting the use of: Vitamin B6 (pyridoxal)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxal or its active form, pyridoxal 5'-phosphate) has some scientific evidence supporting its use in depression, though the evidence is of low to moderate quality and is not definitive. Vitamin B6 is essential for the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are implicated in mood regulation. Deficiencies in vitamin B6 have been associated with depressive symptoms in observational studies. Some clinical trials have investigated B6 supplementation, either alone or in combination with other B vitamins (such as folate and B12), and found modest improvements in mood, particularly in people with low baseline levels of the vitamin or those with elevated homocysteine.

However, most large, well-controlled studies have not demonstrated a robust or consistent antidepressant effect of B6 supplementation in the general population. Reviews and meta-analyses suggest that while B6 is important for brain health and neurotransmitter metabolism, supplementation is unlikely to have a significant impact on depression unless a deficiency is present. Therefore, while there is a scientific rationale and some clinical data to support its use in specific populations, the overall strength of evidence is limited, and B6 is not considered a primary or stand-alone treatment for depression.

More about Vitamin B6 (pyridoxal)
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Other ingredients used for Depression

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acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
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caffeine
cannabis sativa oil
chamomile
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choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
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spirulina
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almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
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zinc
suma
gastrodia
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trace minerals
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cocoa
thyroid substance
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Devil's Club
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Estrogen
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jasmine
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walnut
yohimbine
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Products containing Vitamin B6 (pyridoxal)

We currently have no products on Caring Sunshine that contain this ingredient.