Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been studied for its potential role in supporting or treating depression, with some scientific rationale underlying its use. Vitamin B6 is a cofactor in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are involved in mood regulation. Some observational studies have found that individuals with depression may have lower plasma levels of vitamin B6 compared to healthy controls. Additionally, randomized controlled trials have explored whether supplementation can improve depressive symptoms, particularly in populations at risk of deficiency, such as the elderly or those with poor diets.

However, the overall quality and consistency of evidence are limited. Most studies have small sample sizes, and results are mixed. Some trials suggest modest improvements in mood with B6 supplementation, especially when combined with other B vitamins (such as B12 and folate), but others show no significant effect compared to placebo. Systematic reviews generally conclude that while there is a biological plausibility for B6's involvement in mood regulation, robust clinical evidence to support its use as a standalone treatment for depression is lacking. Therefore, while scientific interest exists and some preliminary data are available, the evidence base is not strong enough to warrant high confidence in its efficacy for this indication.

More about Vitamin B6 (Mixed)
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
Acetyl L-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
Waterhyssop
basil
bergamot
beta caryophyllene
Bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
Cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
Greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
Marine lipid
Matcha
Melatonin
Moringa
Muira puama
N-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
Rhodiola
rose oil
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
spirulina
Tongkat ali
Almond fruit
Valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
Whey protein
Zinc
suma
gastrodia
Mugwort
alpinia galangal
commiphora
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peony
lingzhi
lemongrass
kanna
cistanche
dodder
Morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
Yerba mate
hypothalamus
cocoa
thyroid substance
star of Bethlehem
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
arginine creatine
Ardisia
Angelica
apigenin
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Agmatine
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Alpha lactalbumin
Asteraceae
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aniracetam
Amor seco
betony
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biopterin
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Beef liver
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brahmi
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bee products
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biogenic amine
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crocin
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docosahexaenoic Acid
D-phenylalanine
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devil\'s club
dopamine
egg
Eicosatetraenoic acid
eicosapentaenoic acid
estrogen
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fish
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gastrodin
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hyperforin
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hemp
isoliquiritigenin
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icariin
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inositol phosphate
jasmine
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Oxindole alkaloids
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rue
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rose
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Salidroside
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Walnut
Xanthophyll
Xylaria nigripes
Yuzu
Yerba buena
Yohimbine
Ylang ylang
Zucchini
Zingiberene

Products containing Vitamin B6 (Mixed)

We currently have no products on Caring Sunshine that contain this ingredient.