Evidence supporting the use of: Vitamin B6
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is supported by some scientific evidence for its role in supporting or treating depression, though the evidence is not robust. Vitamin B6 is a coenzyme involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play important roles in mood regulation. Several observational studies have found associations between low B6 status and an increased risk of depressive symptoms. For example, some research suggests that individuals with depression may have lower levels of B6 compared to healthy controls. Randomized controlled trials (RCTs) evaluating B6 supplementation alone for depression are limited and have shown mixed results, with some small studies reporting modest improvements, particularly in specific populations (such as premenstrual women or the elderly), while others find no significant benefit. B6 is often studied in combination with other B vitamins (such as folate and B12), making it difficult to isolate its independent effects. Professional guidelines do not currently recommend B6 supplementation as a primary treatment for depression, but clinicians may consider correcting deficiencies as part of a broader strategy. In summary, while there is some scientific rationale and preliminary evidence for vitamin B6 in managing depression, the overall quality and quantity of evidence is limited, and more high-quality RCTs are needed to establish its efficacy.

More about vitamin B6
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Acetyl L-carnitine
Acetyl-L-Tyrosine
Agarwood
Agmatine
Albizia
algal oil
Algal protein
Almond fruit
Alpha lactalbumin
alpha-linolenic acid (ALA)
alpinia galangal
amino acids
Amor seco
anchovies
Angelica
aniracetam
anthocyanins
apigenin
Ardisia
arginine creatine
ashwagandha
Asteraceae
Bacopa
Bacopin
bacoside
baicalin
Baikal Skullcap
basil
bee products
Beef liver
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacterium longum
biogenic amine
biopterin
Black Hellebore
black tea
blackboard tree
brahmi
Broussonetia
Butea monosperma
butyric acid
bасора
Caesalpinia crista
caffeine
Camellia sinensis
cannabichromene
cannabidiol
Cannabis sativa oil
Canscora
caryophyllene
catalpol
Centella asiatica
chamomile
Chinese raisintree
Chinese salvia root
chocolate
choline
cistanche
citicoline
Citrus
Clary sage
clove
cocoa
coconut
Codonopsis
coenzyme Q10 (CoQ10)
cola nut
commiphora
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
cowslip
creatine
creatine monohydrate
crocin
Curcuma
curcumen
curcumin
Curcuminoid
Cymbopogon martini
D-phenylalanine
damiana
devil\'s club
DHA (docosahexaenoic acid)
DHEA
DHEA (dehydroepiandrosterone)
docosahexaenoic Acid
dodder
dopamine
DPA (docosapentaenoic acid)
egg
eicosapentaenoic acid
Eicosatetraenoic acid
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
estrogen
fatty acids
fish
fish oil
fish protein
flavonoids
flavonols
folate
folic acid
folinic acid
fragrant rosewood
frankincense
fungus
gardenia
gastrodia
gastrodin
ginger
ginkgo biloba
ginseng
Ginsenosides
Glutamate
Glycine
gotu kola
Greek mountain tea
green tea
Griffonia simplicifolia
guanidinoacetic acid
Gypenoside
Helicteres isora
Hellebore
hemp
hemp oil
hericium mushroom
Honokiol
hyperforin
Hypericin
Hypericum
icariin
Indian fagonia
Indian frankincense
Indian tinospora
inositol
inositol phosphate
isoliquiritigenin
jasmine
Jatamansi
jujube
kanna
Kokilaksha
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactium casein decapeptide
lactoglobulin
Large-leaved linden
Lavandin
lavender
Lebbek
lemon balm
lemongrass
ligustilides
limonene
linalool
lingzhi
lion's mane
lipids
liquid liver fractions
lithium orotate
little ironweed
long pepper
luteolin
Lycopodium
maca
magnesium
magnolia
magnolol
Marine fat
Marine lipid
Marine protein
Matcha
Meadow sage
Melatonin
Mesembrine
Methylcobalamin
Methylxanthine
Milk Protein
Mimosa
Monkey flower
Morinda
Moringa
Mugwort
Muira puama
Mulungu
N-acetyl-cysteine (NAC)
Nardostachys
Nigella seed
Nutmeg
Nymphaea caerulea
Nymphaea nouchali
omega-3 fatty acids
Onosma bracteatum
Oroxylum indicum
Osthole
Oxindole alkaloids
paeoniflorin
Palmitoylethanolamide (PEA)
Patchouli oil
Pentacyclic triterpenoids
peony
Petiveria
phenolic compounds
Phenylethylamine (PEA)
phosphatidylserine
Phosphocreatine
phospholipids
Physalis angulata
phytocannabinoids
Phytoestrogens
Piper nigrum
poly-thyronine
Polygala
polygala root
Polygonatum
polyphenols
polyunsaturated fat
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
Pulsatilla
Purple Monkeyflower
pyrroloquinoline quinone
quercetin
reishi mushroom
resveratrol
Rhodiola
Rosabin
rosavins
rose
rose oil
rosemary
rosmarinic acid
royal jelly
Rubiaceae
rue
Safed musli
saffron
Safranal
sage
Salidroside
Salmon Oil
Salvia
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sandalwood
Sarcosine
sceletium
Schizochytrium Oil
Scleranthus annus
selenium
Sensitive Plant
Sete sangrias
Shankhpushpi
Shilajit
Sichuan Lovage
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
Spikenard
spirulina
St. John's Wort
star of Bethlehem
Stereospermum
Sulbutiamine
suma
Sweet Orange alcohol
Tea
Terpenoids
Tetrahydropalmatine
Thymoquinone
thyroid substance
Tongkat ali
trace minerals
Trichilia catigua
Tumerone
turmeric
Uncaria
Uridine
Valerian root
velvet bean
Vervain
Vetiver
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
Walnut
Waterhyssop
Whey protein
Withanolides
Wogonin
Wulinshen
Xanthophyll
Xylaria nigripes
Yerba buena
Yerba mate
Ylang ylang
Yohimbine
Yuzu
Zinc
Zingiberene
Zucchini

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave