Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 has a scientifically recognized role in supporting neurological function and mental health, including mood regulation. Low levels of Vitamin B12 are associated with symptoms of depression and cognitive impairment, particularly among older adults and those with malabsorption syndromes or restrictive diets (e.g., vegans). Several observational studies have found a correlation between B12 deficiency and increased risk or severity of depressive symptoms. A few randomized controlled trials (RCTs) have examined the use of B12 supplementation—either alone or in combination with other B vitamins (notably folate and B6)—as an adjunct to antidepressant therapy. Some of these studies suggest modest improvement in depressive symptoms when B12 is used as part of a broader supplementation regimen, especially in individuals with documented deficiencies. However, the evidence is inconsistent, with some RCTs finding no significant benefit in non-deficient populations. Systematic reviews generally conclude that while B12 deficiency should be screened for and corrected in individuals with depression, there is limited evidence to support routine supplementation for depression in individuals with normal B12 levels. Thus, while there is a scientific basis for its use in specific contexts (notably deficiency states), the overall evidence supporting its use as a primary treatment for depression is limited, justifying a moderate rating.

More about Vitamin B12 (various)
More about Depression

Other ingredients used for Depression

Other health conditions supported by Vitamin B12 (various)

Products containing Vitamin B12 (various)