Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Turmerone is a bioactive compound found in turmeric (Curcuma longa) essential oil, distinct from the more commonly studied curcumin. There is preliminary scientific evidence suggesting that turmerone may have antidepressant-like effects, primarily from animal studies. Research indicates that turmerone can modulate neurotransmitter systems, particularly serotonin and dopamine, which are implicated in depression. For example, a 2015 study in mice found that ar-turmerone exerted antidepressant-like effects in behavioral tests and influenced brain-derived neurotrophic factor (BDNF) expression, a key molecule in mood regulation (Zhu et al., 2015). However, clinical trials in humans are lacking, and the available evidence is not sufficient to draw firm conclusions about turmerone's efficacy for depression in people. While turmeric has a long history of use in traditional medicine for various ailments, turmerone itself is not specifically cited in traditional texts for depression. The current scientific validation is limited to preclinical studies, and further research, especially human clinical trials, is needed to determine safety, efficacy, and appropriate dosing. Therefore, while the idea is scientifically plausible, the evidence is still early and not robust enough to fully support turmerone as a treatment for depression.

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