Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thyroid substance (desiccated thyroid extract or synthetic thyroid hormones) has a scientific basis for use as an adjunct in the treatment of depression, particularly in specific subpopulations. The relationship between thyroid function and mood disorders is well-established: hypothyroidism frequently manifests with depressive symptoms, and correcting thyroid deficiency often leads to significant mood improvement. Moreover, some studies have shown that adding thyroid hormone—especially triiodothyronine (T3)—can accelerate or augment the antidepressant response in patients with treatment-resistant depression, even when thyroid function is within the normal range. This strategy is more established with T3 (liothyronine) than with desiccated thyroid or levothyroxine (T4), and it is typically reserved for patients who have not responded adequately to standard antidepressant therapies.

Meta-analyses and randomized controlled trials suggest a modest yet statistically significant benefit in some cases, but the effect size is variable and the quality of evidence is moderate. The overall consensus in guidelines is that thyroid augmentation may be helpful as a second-line or adjunctive therapy for depression, especially in cases with subclinical or overt hypothyroidism, or in select euthyroid patients who are resistant to antidepressants. Nonetheless, routine use in all patients with depression is not recommended, and monitoring for side effects (such as cardiac arrhythmias or bone loss) is essential. Thus, while the practice is grounded in scientific observation and evidence, it is not a primary or universal treatment.

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Nature's Sunshine Thyroid Support