Synopsis

Source of validity: Scientific
Rating (out of 5): 4

St. John's Wort (Hypericum perforatum) is an herbal remedy that has been traditionally used for centuries to treat mood disorders, especially depression. However, in recent decades, its use for mild to moderate depression has received significant scientific scrutiny. Several randomized, double-blind, placebo-controlled trials and meta-analyses have demonstrated that standardized extracts of St. John's Wort are more effective than placebo and similarly effective to standard antidepressants (such as SSRIs) in treating mild to moderate depression. For example, a 2017 Cochrane review analyzed 29 trials and concluded that St. John’s Wort extracts were superior to placebo and similarly effective as standard antidepressants, with fewer side effects. The active constituents, including hypericin and hyperforin, are believed to influence neurotransmitter activity (such as serotonin, dopamine, and norepinephrine), though the precise mechanisms remain under investigation.

Despite this evidence, St. John's Wort is not universally recommended due to variability in product quality, differences in extract standardization, and significant interactions with many prescription medications (notably oral contraceptives, anticoagulants, and some antidepressants). While it appears to be a valid option for some individuals with mild to moderate depression, it is not recommended for severe depression or bipolar disorder, and healthcare provider supervision is crucial.

More about St. John's Wort
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Other ingredients used for Depression

Other health conditions supported by St. John's Wort

Products containing St. John's Wort

Nature's Sunshine St. John's Wort (Concentrated)
Nature's Sunshine St. John's Wort (Concentrated Time Release)