Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sphaeranthus indicus, commonly known as East Indian globe thistle, has a long history of use in traditional Ayurvedic and folk medicine systems in India. Traditionally, it has been employed for a variety of neurological and psychiatric disorders, including as a “medhya rasayana” (nootropic or brain tonic) and specifically for mood disorders like depression and anxiety. The plant is believed to possess calming, mood-stabilizing, and adaptogenic properties based on its use in classical Ayurvedic texts and regional folk practices.

Scientific research into the antidepressant effect of Sphaeranthus indicus is limited but emerging. Preclinical animal studies (such as those published in Journal of Ethnopharmacology and Phytomedicine) have reported that extracts of the plant exhibit antidepressant-like effects in rodent behavioral models (e.g., forced swim test, tail suspension test), possibly via modulation of monoamine neurotransmitters and antioxidant mechanisms. However, these studies are few, have small sample sizes, and lack human clinical trials.

Thus, while there is some preclinical evidence to suggest a plausible biological activity relevant to depression, the primary justification for its use in depression remains traditional. More robust clinical research is required to substantiate its efficacy and safety for this indication.

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