Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Shellfish, such as oysters, mussels, and shrimp, are sometimes referenced in scientific literature as potentially supportive for mood and depression, largely due to their nutrient profile. Shellfish are rich sources of omega-3 fatty acids (notably EPA and DHA), vitamin B12, zinc, selenium, and other micronutrients that have been implicated in brain health and neurotransmitter function. Several studies have observed that individuals with diets higher in omega-3 fatty acids may have a lower risk of depression, and deficiencies in vitamin B12 and zinc are associated with depressive symptoms. However, most of the robust evidence relates to fish (especially oily fish) rather than shellfish specifically. Intervention studies using omega-3 supplementation (often derived from fish oil) have shown mixed but sometimes positive results for depression, but data specifically on shellfish consumption and depression is limited. There is little evidence of a traditional or folk medicine use of shellfish specifically for mood disorders. In summary, shellfish may contribute to overall nutrient adequacy that supports mental health, but direct evidence for their use in treating depression is modest and mostly extrapolated from broader studies on nutrients found in seafood. Therefore, the evidence level is rated as 2 out of 5.

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