Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Salvia, a genus encompassing many species including Salvia officinalis (common sage) and Salvia miltiorrhiza (Danshen), has a long history of traditional use in various cultures. For depression, Salvia species have traditionally been employed in folk medicine systems, particularly in Europe and Asia, to support mood and cognitive function. For example, Salvia officinalis has been used in European herbalism to promote emotional well-being and reduce symptoms associated with low mood. Similarly, Salvia miltiorrhiza is utilized in Traditional Chinese Medicine (TCM), often as part of multi-herb formulas, to "invigorate the blood" and calm the mind, which may indirectly relate to mood regulation.

However, the scientific evidence supporting the use of Salvia species for depression is limited. A small number of preliminary studies suggest possible mood-enhancing or neuroprotective effects for some Salvia species, but robust clinical trials are lacking. The most studied species in this context, Salvia officinalis, has some evidence indicating cognitive benefits and mild mood improvements, but these studies are generally small and not definitive for treating depression. Salvia divinorum, a psychoactive species, has some anecdotal reports of mood effects, but its use is not sanctioned for medical purposes and lacks clinical validation for depression. Overall, while there is a foundation of traditional use, high-quality scientific evidence is sparse.

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