Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Sagebrush is a common name for several species in the Artemisia genus, such as Artemisia tridentata. There is traditional use of sagebrush among some Native American groups for spiritual purposes, as well as for a variety of ailments including fever, infections, and sometimes for general wellness. However, its use specifically for depression is not well-documented in the ethnobotanical or historical literature. Most references to the use of sagebrush relate to its application as a ceremonial plant (for smudging or cleansing), or for gastrointestinal, respiratory, and topical conditions. There are no high-quality clinical trials or robust scientific evidence supporting the use of sagebrush for treating depression. Phytochemical studies have identified various bioactive compounds in sagebrush, such as sesquiterpene lactones and essential oils, but these have not been specifically linked to antidepressant effects in controlled studies. Overall, while there may be minor traditional associations with mood or spiritual well-being, sagebrush is not widely recognized in either traditional medicine or scientific research as a treatment for depression.

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