Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Rehmannia (Rehmannia glutinosa), a key herb in traditional Chinese medicine (TCM), is primarily used to nourish the yin and tonify the blood. In TCM, imbalances in yin and blood are sometimes associated with symptoms resembling depression, such as low mood, fatigue, and emotional instability. Historically, Rehmannia has been included in herbal formulas intended to address such symptoms, but always as part of a larger combination rather than as a standalone remedy for depression. There is sparse modern clinical research directly examining Rehmannia’s effects on depressive disorders. Most available evidence comes from animal studies or cell-based assays suggesting potential neuroprotective and anti-inflammatory properties, but these do not directly translate into validated antidepressant effects in humans. Systematic reviews and meta-analyses of herbal treatments for depression rarely single out Rehmannia as a primary component with proven efficacy. Therefore, its use for depression is justified mainly by traditional practice rather than scientific validation, and the quality of supporting evidence is low.

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