Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has garnered scientific interest for its potential role in supporting or treating depression. Preclinical studies in animal models have demonstrated that resveratrol may exert antidepressant-like effects, possibly by modulating neurotransmitter levels (such as serotonin, dopamine, and norepinephrine) and reducing neuroinflammation and oxidative stress. These effects are thought to be mediated through pathways involving SIRT1 activation, the HPA axis, and BDNF signaling, all of which are implicated in mood regulation.

A handful of small human studies and pilot clinical trials have examined resveratrol’s effects on mood or depressive symptoms. While some findings suggest a potential improvement in depressive symptoms, the evidence is preliminary and not robust. Most human data come from studies where resveratrol was used as an adjunctive therapy rather than a primary treatment. Moreover, dosing, bioavailability, and long-term safety remain unclear, and there is a lack of large-scale, well-controlled clinical trials directly evaluating resveratrol for depression.

In summary, while there is some scientific rationale and early evidence supporting resveratrol’s potential antidepressant effects, the overall quality and quantity of human evidence are limited. More rigorous clinical studies are required before resveratrol can be recommended as a treatment for depression.

More about resveratrol
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Other ingredients used for Depression

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Products containing resveratrol

Nature's Sunshine Cardio Assurance
Nature's Sunshine Cholester-Reg II
Nature's Sunshine Nattozimes Plus
Nature's Sunshine Solstic Cardio
Nature's Sunshine Super ORAC