Evidence supporting the use of: Pyrroloquinoline quinone disodium salt
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline quinone disodium salt (PQQ) has garnered some attention as a potential supplement to support mood and cognitive function, including depression. The scientific rationale is based on PQQ's role as a redox cofactor with antioxidant properties and its ability to modulate mitochondrial function and cellular signaling pathways. Animal studies have suggested that PQQ supplementation may attenuate stress-induced behavioral changes and reduce markers of oxidative stress and inflammation, which are implicated in the pathophysiology of depression.

Human data, however, remain limited. A small number of clinical studies—mostly open-label or pilot trials—have reported improvements in mood, fatigue, and sleep in participants taking PQQ supplements, but these studies often include mixed populations and subjective endpoints, with depression measured as part of broader quality-of-life assessments. For example, a 2012 open-label clinical trial (Nakano et al.) found that PQQ supplementation improved subjective measures of fatigue, sleep, and mood in healthy adults, but did not specifically target individuals with clinical depression or use standardized depression scales as primary outcomes.

In summary, while there is some preliminary scientific evidence and plausible biological mechanisms for PQQ's benefits in relation to mood and potentially depression, high-quality, large-scale randomized controlled trials focused specifically on depression are lacking. Therefore, current evidence supporting PQQ for depression is limited and should be regarded as preliminary.

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Products containing Pyrroloquinoline quinone disodium salt

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