Polygonatum cirrhifolium, commonly known as "Solomon's Seal," is a plant traditionally used in various systems of traditional medicine, including Ayurveda and Traditional Chinese Medicine. Its roots and rhizomes are primarily used for their purported adaptogenic, tonic, and rejuvenating properties. In some traditional practices, Polygonatum species are employed to support general health, alleviate fatigue, and sometimes to calm the mind, which may be loosely connected to mood or emotional wellbeing. However, there is no specific, documented, or widespread traditional use of Polygonatum cirrhifolium for the direct treatment or support of depression as a medical condition. The association with depression management is primarily speculative or based on its general adaptogenic and tonic uses, which might be interpreted as supportive for mental health.

There are no robust scientific studies or clinical trials that specifically evaluate Polygonatum cirrhifolium for antidepressant activity or for the treatment of depressive disorders. The available evidence is limited to ethnobotanical surveys and traditional references, lacking any direct preclinical or clinical validation for depression. Therefore, the use of Polygonatum cirrhifolium for depression is justified at best by tradition, and the strength of evidence is weak.