Evidence supporting the use of: Pentacyclic triterpenoids (unspecified)
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pentacyclic triterpenoids, a class of naturally occurring compounds found in various medicinal plants (such as betulinic acid, oleanolic acid, and ursolic acid), have been studied for their potential neuroprotective and antidepressant effects. Preclinical studies, mainly in animal models, suggest that certain pentacyclic triterpenoids may exert antidepressant-like effects. These effects are thought to occur through mechanisms such as modulation of the hypothalamic-pituitary-adrenal (HPA) axis, enhancement of neurotrophic factors (like brain-derived neurotrophic factor, BDNF), attenuation of neuroinflammation, and antioxidative actions. For example, asiaticoside (from Centella asiatica) and ursolic acid have demonstrated antidepressant-like activity in rodent behavioral tests, sometimes comparable to standard antidepressants. However, most of the current evidence comes from laboratory and animal studies, and there is a lack of large-scale, well-controlled clinical trials in humans. There is no tradition of these compounds being directly used for depression in folklore medicine; their use is more recent and research-driven. In summary, while there is some scientific rationale and preliminary evidence supporting the antidepressant potential of pentacyclic triterpenoids, the strength of evidence is low (rated 2/5), and clinical validation in humans is still insufficient.

More about Pentacyclic triterpenoids (unspecified)
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Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
tongkat ali
almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
whey protein
zinc
suma
gastrodia
mugwort
alpinia galangal
commiphora
blackboard tree
caesalpinia crista
peony
lingzhi
lemongrass
kanna
cistanche
dodder
morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
yerba mate
hypothalamus
cocoa
thyroid substance
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
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Ardisia
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Apigenin
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Agmatine
Agarwood
Alpha lactalbumin
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Amor seco
Betony
Baikal Skullcap
Broussonetia
Beta-hydroxybutyrate
Biopterin
Butea monosperma
Beef liver
Bacopin
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Bacopa
Bee products
bacoside
Baicalin
Black Hellebore
Biogenic amine
Camellia sinensis
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Caryophyllene
Common Monkey Flower
Crocin
Clary sage
Catalpol
Codonopsis
Curcuminoid
Citrus
Chinese Raisintree
Curcumen
Cymbopogon Martini
Centella asiatica
Chocolate
Creatine
Curcuma
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Folinic Acid
Folic Acid
Flavonoids
Fragrant Rosewood
Fish
Fatty acids
Frankincense
Guanidinoacetic acid
Ginsenosides
Griffonia simplicifolia
Glutamate
Glycine
Gastrodin
jasmine
Little ironweed
Milk Protein
Mimosa
Phenylethylamine (PEA)
Rose
Spikenard
Shellfish
Sandalwood
Sweet Orange alcohol
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walnut
yohimbine
Zucchini

Products containing Pentacyclic triterpenoids (unspecified)

We currently have no products on Caring Sunshine that contain this ingredient.