Synopsis

Source of validity: Scientific
Rating (out of 5): 3

There is emerging scientific evidence that certain mushrooms, particularly Psilocybe species (containing the psychedelic compound psilocybin), may have therapeutic potential for depression. Clinical trials have indicated that psilocybin-assisted therapy can produce rapid and sustained reductions in depressive symptoms, even in cases of treatment-resistant depression. For example, a 2020 randomized clinical trial published in JAMA Psychiatry found that psilocybin, when administered with psychological support, led to significant decreases in depression scores compared to a waitlist control. Other studies have demonstrated similar effects, with benefits persisting for weeks or months after treatment. The proposed mechanisms include increased neuroplasticity, altered brain network connectivity, and facilitation of emotional processing.

However, it is important to note that these effects are specific to psilocybin-containing mushrooms and not to culinary varieties like shiitake or button mushrooms. Additionally, psilocybin treatment is not yet widely available or approved outside of research settings, and more large-scale, long-term studies are needed to fully establish efficacy and safety. While traditional use of psychoactive mushrooms for spiritual and healing purposes exists in some cultures, the current interest in depression treatment is primarily driven by scientific research.

More about Mushroom (various)
More about Depression

Other ingredients used for Depression

Other health conditions supported by Mushroom (various)

Products containing Mushroom (various)