Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Medium Chain Triglycerides (MCTs) have been investigated for their potential effects on brain function, including mood and depression. The rationale for their use is primarily based on the role of MCTs in ketogenic diets, which can elevate ketone body production and provide alternative energy sources for the brain. Some preliminary studies and animal models suggest that ketones may have neuroprotective, anti-inflammatory, and potentially mood-stabilizing effects. A few small-scale human studies have indicated that ketogenic diets, which often include MCTs, may reduce depressive symptoms, particularly in individuals with treatment-resistant depression or certain neurological conditions. However, high-quality randomized controlled trials directly examining MCT oil supplementation for depression in the general population are lacking. Most existing evidence is indirect, and the mechanisms by which MCTs might influence mood are not fully understood. As of now, the evidence base is limited and rated as low (2/5), indicating that while there is some scientific rationale and preliminary data, it is not yet robust or conclusive. Clinical guidelines do not currently recommend MCTs as a treatment for depression.

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