Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium threonate is a form of magnesium that has gained attention due to its ability to increase magnesium levels in the brain more effectively than other forms. Magnesium itself has been studied for its potential role in supporting mood and mental health, as deficiencies in magnesium have been associated with depressive symptoms. Some preclinical studies (mainly in animal models) suggest that magnesium threonate may improve synaptic plasticity and cognitive function, which could theoretically influence mood regulation. A few small-scale human studies and case reports have linked magnesium supplementation to improvements in depressive symptoms, but these generally use other forms of magnesium and focus on populations with magnesium deficiency.

Direct scientific evidence specifically evaluating magnesium threonate for depression in humans is limited. Most available clinical trials on magnesium threonate center on cognitive function and age-related memory loss rather than depression. Thus, while there is a plausible biological rationale for magnesium’s role in mood support, and magnesium threonate is promising for brain delivery, robust human studies confirming its efficacy for depression are lacking. Overall, the evidence supporting the use of magnesium threonate for depression is preliminary and not yet strong enough to warrant clinical recommendations.

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