Evidence supporting the use of: Maca
For the health condition: Depression
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Maca (Lepidium meyenii) is a root vegetable native to the Andes in Peru and has been used traditionally for centuries to enhance stamina, fertility, and general well-being. In traditional medicine, especially among indigenous Andean populations, maca has also been employed as a natural remedy to improve mood and alleviate symptoms that may be associated with depression, such as fatigue and lack of motivation. The rationale stems from its adaptogenic properties, with the belief that it helps the body better cope with stress and emotional imbalances.
Scientific investigation into maca’s effects on depression is limited but growing. A small number of animal studies and preliminary human trials suggest that maca may influence mood by modulating hormone levels or supporting neurotransmitter balance, possibly reducing symptoms of depression, especially in specific populations like postmenopausal women. For example, a 2008 double-blind, placebo-controlled study found that maca improved psychological symptoms, including depression, in postmenopausal women. However, these studies are limited by small sample sizes, short durations, and methodological weaknesses.
Overall, the primary justification for using maca to support or treat depression is rooted in tradition, with modest supporting evidence from early-stage scientific research. More robust, large-scale clinical trials are required before maca can be recommended based on strong scientific validation.
Other ingredients used for Depression
5-Hydroxytryptophan (5-HTP)acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
tongkat ali
almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
whey protein
zinc
suma
gastrodia
mugwort
alpinia galangal
commiphora
blackboard tree
caesalpinia crista
peony
lingzhi
lemongrass
kanna
cistanche
dodder
morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
yerba mate
hypothalamus
cocoa
thyroid substance
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Arginine Creatine
Ardisia
Angelica
Apigenin
Albizia
Agmatine
Agarwood
Alpha lactalbumin
Asteracea
Algal protein
Aniracetam
Amor seco
Betony
Baikal Skullcap
Broussonetia
Beta-hydroxybutyrate
Biopterin
Butea monosperma
Beef liver
Bacopin
Brahmi
Bacopa
Bee products
bacoside
Baicalin
Black Hellebore
Biogenic amine
Camellia sinensis
Coconut
Caryophyllene
Common Monkey Flower
Crocin
Clary sage
Catalpol
Codonopsis
Curcuminoid
Citrus
Chinese Raisintree
Curcumen
Cymbopogon Martini
Centella asiatica
Chocolate
Creatine
Curcuma
Cowslip
Cannabidiol
Convolvulus prostratus
Convolvulus Pluricaulis
cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Glycine
jasmine
Little ironweed
Milk Protein
Mimosa
Phenylethylamine (PEA)
Rose
Spikenard
Sandalwood
Sweet Orange alcohol
Vervain
walnut
yohimbine
Zucchini
Other health conditions supported by maca
Adrenal FatigueAmenorrhea
Anemia
Anxiety
Athletic and Exercise Aids
Depression
Diabetes
Energy (lack of)
Erectile Dysfunction
Fatigue
Hot Flashes
Infertility
Insomnia
Irritability
Memory and Brain Function
Menopause
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Miscarriage (prevention)
Mood Swings
Muscle Tone (lack of)
Nervous Exhaustion
Nocturnal Emission
Osteoporosis
PMS (general)
Progesterone (low)
Puberty (hormone balancer)
Sex Drive (low)
Stress
Testosterone (low)