Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Linalool is a naturally occurring terpene alcohol found in many flowers and spices, including lavender. Its potential use in supporting or treating depression is primarily based on preclinical (animal and in vitro) studies rather than large-scale human clinical trials. Research has demonstrated that linalool may exert antidepressant-like effects in animal models, possibly by modulating neurotransmitter systems such as serotonin, dopamine, and glutamate. Additionally, linalool has been shown to reduce stress and anxiety-related behaviors in rodents, which are often comorbid with depressive symptoms.

Mechanistically, linalool is believed to interact with the central nervous system, potentially influencing GABAergic transmission and reducing neuroinflammation — factors implicated in mood disorders. Inhalation and oral administration of linalool in animal studies have led to reduced depressive-like behavior, supporting its possible therapeutic role.

However, direct evidence from human clinical trials is very limited. Most human data are indirect, typically relating to the effects of aromatherapy with lavender oil (rich in linalool), which has shown some benefit for anxiety and mood, but not specifically for clinical depression. As such, while there is promising preclinical evidence, robust scientific validation in humans remains lacking, and the current evidence rating is low to moderate (2/5).

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