Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hemp oil, often referred to as CBD oil when extracted from industrial hemp, has gained attention as a potential aid for depression. The primary active component of hemp oil is cannabidiol (CBD), a non-psychoactive compound that interacts with the body’s endocannabinoid system, which is involved in regulating mood, stress response, and other physiological processes. Several preclinical studies (in animals) and a handful of small-scale human studies suggest that CBD may exert anxiolytic and antidepressant-like effects, possibly by influencing serotonin receptors and reducing inflammation in the brain.

However, the current scientific evidence supporting the use of hemp oil for depression is limited and preliminary. Most clinical studies are small, lack rigorous controls, or focus on related symptoms such as anxiety or sleep disturbances rather than depression as a primary outcome. A 2020 review in the journal CNS Drugs concluded that while preclinical results are promising, high-quality clinical trials are scarce and results are mixed. The FDA has not approved CBD for depression treatment, and major psychiatric organizations do not currently recommend its use as a first-line treatment.

In summary, while there is some scientific rationale and early evidence suggesting hemp oil may help with depression, the evidence base is weak (rated 2/5), and more large-scale, well-designed studies are needed before it can be recommended as a mainstream treatment. Individuals should consult healthcare providers before using hemp oil for depression.

More about hemp oil
More about Depression

Other ingredients used for Depression

Other health conditions supported by hemp oil

Products containing hemp oil