Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Goldthread (Coptis spp., often Coptis chinensis) has a long history of use in traditional Chinese medicine (TCM), primarily for its antimicrobial, anti-inflammatory, and "heat-clearing" properties. While it contains active compounds such as berberine, which have been studied for a variety of health effects, there is little direct traditional documentation supporting its use specifically for depression. In some TCM formulations, goldthread may be included as part of broader herbal combinations aimed at addressing mood and emotional imbalances, but it is not a primary or classic herb for depression in either Eastern or Western herbal traditions. Scientific validation for goldthread's use in treating or supporting depression is lacking; clinical trials or animal studies evaluating its efficacy for depression are minimal to nonexistent. Most research focuses on its antimicrobial, anti-diabetic, and cardiovascular effects. In summary, the use of goldthread for depression is based more on traditional, anecdotal, or secondary uses rather than direct historical or scientific evidence.

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