Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Oriental ginseng (Panax ginseng) has a long history of use in traditional Chinese and Korean medicine for enhancing vitality, reducing fatigue, and improving well-being, which sometimes includes symptoms overlapping with depression. Traditionally, ginseng is classified as an adaptogen, believed to help the body resist stressors of various kinds, including psychological stress. In traditional texts, ginseng has been recommended for "calming the spirit" and improving mood.

Scientifically, some limited studies have investigated the potential antidepressant effects of Panax ginseng. Preclinical research (animal models) suggests that ginsenosides, the active compounds in ginseng, may influence neurotransmitters such as serotonin and dopamine, which are associated with mood regulation. However, high-quality human clinical trials specifically evaluating ginseng for depression are scarce, and results are inconsistent. Systematic reviews generally conclude that while there is some preliminary evidence of mood-enhancing effects, the quality and quantity of evidence are not sufficient to support routine use for depression. Most of the endorsement for ginseng's use in depression comes from traditional practice rather than robust scientific validation.

In summary, the use of Oriental ginseng for depression is justified mainly by tradition, with some suggestive but not conclusive scientific evidence. Further well-designed clinical studies are needed to clarify its efficacy and safety for this indication.

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