Evidence supporting the use of: Flavonoids
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a class of polyphenolic compounds found abundantly in fruits, vegetables, tea, and other plant-based foods. There is growing scientific interest in the potential of flavonoids to support mental health, including depression. Preclinical studies (animal and cell-based research) suggest that flavonoids may exert antidepressant-like effects by modulating neurotransmitter systems, reducing neuroinflammation, and enhancing neuroplasticity. Some flavonoids, such as quercetin, kaempferol, and epigallocatechin gallate (EGCG), have demonstrated the ability to influence pathways implicated in depression, such as the serotonergic and dopaminergic systems.

Human data, however, are limited. A few observational studies and small clinical trials indicate that diets rich in flavonoids may be associated with a reduced risk of depressive symptoms. For example, a 2018 study published in the journal Nutrients found that higher intake of flavonoid-rich foods was linked to lower rates of depression in a large cohort. However, causality is not established, and intervention studies specifically examining flavonoid supplementation for depression are sparse and often suffer from methodological limitations.

Overall, while there is scientific rationale and preliminary evidence supporting the potential role of flavonoids in depression, robust clinical trials are lacking. Thus, the evidence supporting their use is promising but currently weak (rated 2/5), and flavonoids should not be considered a primary therapy for depression at this time.

More about Flavonoids
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
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caffeine
cannabis sativa oil
chamomile
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choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
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rosemary
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vitamin C
vitamin D
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zinc
suma
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cocoa
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bacoside
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cola nut
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D-phenylalanine
DHEA
Devil's Club
Dopamine
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Eicosatetraenoic acid
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Estrogen
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Folic Acid
Flavonoids
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Fish
Fatty acids
Frankincense
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Ginsenosides
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jasmine
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Products containing Flavonoids

We currently have no products on Caring Sunshine that contain this ingredient.