Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fish protein, specifically from fatty fish rich in omega-3 polyunsaturated fatty acids (PUFAs) such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), has been scientifically investigated for its potential in supporting or treating depression. Several randomized controlled trials and meta-analyses have shown that supplementation with omega-3 fatty acids can have a modest but statistically significant effect on reducing depressive symptoms, particularly in individuals with major depressive disorder. The mechanism is believed to involve modulation of neurotransmitter pathways, anti-inflammatory effects, and neuroprotective actions that may improve brain function and mood regulation.

While the strongest evidence relates to omega-3 supplements rather than whole fish protein, dietary intake of fish protein naturally includes these beneficial fatty acids, along with other nutrients such as vitamin D, B vitamins, and selenium, which may also contribute to mental health. Guidelines from some psychiatric associations recommend considering omega-3 supplementation as an adjunctive therapy for depression. However, not all studies have found a benefit, and the effect size is generally small to moderate. It is also important to note that fish protein itself (apart from its omega-3 content) has not been directly studied as a treatment for depression; rather, the focus is on the fatty acids found in the protein-rich fish.

In summary, there is scientific evidence supporting the role of omega-3s—often consumed via fish protein—in the management of depression, but the evidence is moderate and more robust for supplements than for dietary intake alone.

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