Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Eleutherococcus senticosus, also known as Siberian ginseng, has a long history of use in traditional medicine systems, particularly in Russia, China, and other parts of Asia. Traditionally, it has been used as an "adaptogen," a substance believed to help the body resist physical, chemical, and biological stress, and to improve overall vitality. Its use in the context of depression specifically is largely based on these general adaptogenic claims, with the belief that by enhancing the body's ability to cope with stress, mood and emotional well-being may also improve.

Scientific studies directly investigating Eleutherococcus senticosus for the treatment of depression are limited and generally of low quality. A few small clinical trials and animal studies suggest mild positive effects on mood and cognitive function, potentially attributed to modulation of neurotransmitters and anti-fatigue properties. However, these studies are typically not robust enough to establish efficacy for depression as a clinical diagnosis. Most systematic reviews and authoritative sources (such as the Natural Medicines Comprehensive Database) conclude that there is insufficient reliable evidence to recommend Eleutherococcus senticosus for depression. Therefore, its use for this condition is best characterized as traditional, with minimal scientific validation to date.

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