Evidence supporting the use of: Eleuthero
For the health condition: Depression

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Eleuthero (Eleutherococcus senticosus, also known as Siberian ginseng) has a long history of traditional use in Russian and Chinese medicine as an adaptogen—an agent believed to enhance the body's resistance to various stressors, including psychological stress. In traditional practice, eleuthero has sometimes been used to support emotional well-being and resilience, which may overlap with concepts related to depression. However, direct traditional references to treating clinical depression specifically are sparse; the herb was more commonly used for general fatigue, stress, and vitality.

Modern scientific evidence supporting eleuthero’s efficacy for depression is limited and inconclusive. Some preclinical studies suggest that eleuthero extracts may modulate neurotransmitter systems (such as serotonin and dopamine) implicated in mood regulation, but robust human clinical trials are lacking. A handful of small human studies have investigated eleuthero for fatigue and stress but not for major depressive disorder. As such, while traditional use offers some basis for its application in mood support or stress, the evidence for directly treating depression is weak, primarily anecdotal, and not strongly validated by modern research.

In summary, eleuthero's use for depression is rooted more in traditional, holistic views of health and stress adaptation rather than direct, evidence-based treatment of depressive disorders. Further research is needed to clarify its role, if any, in managing depression.

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Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
acetyl l-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
waterhyssop
basil
bergamot
beta caryophyllene
bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnosine
l-glycine
l-methionine
l-phenylalanine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
mackerel
magnesium
magnolia
marine lipid
matcha
melatonin
moringa
muira puama
n-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
rhodiola
rose oil
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
sceletium
selenium
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
tongkat ali
almond fruit
valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
whey protein
zinc
suma
gastrodia
mugwort
alpinia galangal
commiphora
blackboard tree
caesalpinia crista
peony
lingzhi
lemongrass
kanna
cistanche
dodder
morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
yerba mate
hypothalamus
cocoa
thyroid substance
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Agmatine
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Bee products
bacoside
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Biogenic amine
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Caryophyllene
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Crocin
Clary sage
Catalpol
Codonopsis
Curcuminoid
Citrus
Chinese Raisintree
Curcumen
Cymbopogon Martini
Centella asiatica
Chocolate
Creatine
Curcuma
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Cannabidiol
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Convolvulus Pluricaulis
cola nut
Canscora
Cannabichromene
Docosahexaenoic Acid
D-phenylalanine
DHEA
Devil's Club
Dopamine
Egg
Eicosatetraenoic acid
Eicosapentaenoic Acid
Estrogen
Glycine
jasmine
Little ironweed
Milk Protein
Mimosa
Phenylethylamine (PEA)
Rose
Spikenard
Sandalwood
Sweet Orange alcohol
Vervain
walnut
yohimbine
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