Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Brahmi (Bacopa monnieri) has a long history of use in Ayurvedic medicine for various mental health conditions, including depression, stress, and anxiety. In terms of scientific evidence, a small but growing body of research has examined Brahmi’s effects on mood disorders. Several animal studies have shown antidepressant-like effects of Brahmi extracts, with mechanisms thought to involve modulation of neurotransmitters such as serotonin, dopamine, and noradrenaline. Some human studies and clinical trials have also explored Bacopa’s cognitive and mood-enhancing properties, though most focus on memory, anxiety, and cognitive function, rather than depression specifically.

Limited randomized controlled trials (RCTs) have evaluated Bacopa for depression. Some trials have reported modest improvements in mood or symptoms of depression compared to placebo, but these studies are few, often have small sample sizes, and sometimes use Brahmi in combination formulas rather than as a sole intervention. A 2014 systematic review (Pase et al., 2012; Calabrese et al., 2008) concluded that while Bacopa shows potential for improving cognition and may have anxiolytic effects, evidence for its antidepressant activity in humans remains preliminary and insufficient for firm conclusions. Thus, while scientific interest exists and some early data are promising, the overall quality and quantity of evidence supporting Brahmi as a treatment for depression is currently weak to modest.

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