Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-hydroxybutyrate (BHB) is a ketone body produced during periods of fasting, prolonged exercise, or ketogenic diets. Its potential to support or treat depression has emerged from recent scientific investigations rather than longstanding traditional use. Preclinical studies suggest that BHB may exert neuroprotective and anti-inflammatory effects, which are hypothesized to contribute to antidepressant-like actions. For instance, animal studies have demonstrated that BHB can reduce depressive-like behaviors, possibly by inhibiting the NLRP3 inflammasome and modulating brain-derived neurotrophic factor (BDNF) signaling.

However, clinical evidence in humans is sparse and largely preliminary. A few small pilot studies and case reports indicate that ketogenic diets, which raise endogenous BHB levels, may have mood-stabilizing effects in some individuals with mood disorders, including depression. The direct administration of BHB as a supplement for depression has not been robustly studied in randomized controlled trials. Therefore, while there is a plausible mechanistic rationale and some promising preclinical data, the evidence base in humans remains limited and does not yet justify widespread use of BHB for depression outside of research settings.

In summary, the use of BHB for depression is supported by emerging but still insufficient scientific evidence, and its efficacy and safety for this indication are not yet well established.

More about Beta-hydroxybutyrate
More about Depression

Other ingredients used for Depression

Other health conditions supported by Beta-hydroxybutyrate

Products containing Beta-hydroxybutyrate