Evidence supporting the use of: Angelica gigas nakai
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Angelica gigas Nakai, also known as Korean angelica, has been investigated for its potential antidepressant effects in preclinical studies. The root contains active compounds such as decursin and decursinol angelate, which have demonstrated neuroprotective and anti-inflammatory activities. Several animal studies have reported that extracts from Angelica gigas exhibit antidepressant-like effects in rodent models subjected to behavioral tests such as the forced swim test and tail suspension test. These effects are thought to be mediated by the modulation of monoaminergic systems (e.g., serotonin and dopamine pathways), reduction of neuroinflammation, and antioxidative mechanisms. For example, a 2014 study published in "Phytotherapy Research" found that Angelica gigas extract significantly reduced depressive-like behaviors in mice and suggested possible involvement of the serotonergic system.

However, robust clinical evidence in humans is lacking. There are currently no large-scale, well-controlled human trials that confirm the efficacy or safety of Angelica gigas for the treatment of depression. Most of the available data are limited to animal models and in vitro experiments. Traditional use of Angelica gigas in East Asian medicine has primarily been for circulatory problems, menstrual disorders, and as a tonic rather than specifically for depression. Therefore, while there is some preliminary scientific evidence from animal studies (warranting a rating of 2/5), its use for depression in humans is not yet scientifically validated.

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Products containing Angelica gigas nakai

We currently have no products on Caring Sunshine that contain this ingredient.