Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine is a phospholipid found in high concentrations in the brain and is involved in cell membrane integrity and signaling. Its use for dementia and cognitive decline is primarily supported by scientific interest, although the overall quality and quantity of evidence is moderate at best. Several small-scale clinical trials from the 1980s and 1990s, primarily using phosphatidylserine derived from bovine cortex, suggested potential benefits for memory, mood, and cognitive function in elderly subjects with dementia, including Alzheimer's disease. However, due to concerns about prion contamination, current supplements are sourced from soy or cabbage, and these plant-derived forms may have different efficacy profiles. Recent studies using plant-derived phosphatidylserine show mixed results. Some randomized controlled trials report modest improvements in memory and cognition, particularly in older adults with age-associated memory impairment, but others find no significant benefit over placebo. Meta-analyses generally conclude that while there may be some positive trends, the overall evidence is limited by small sample sizes, short study durations, and methodological issues. Major clinical guidelines do not currently recommend phosphatidylserine for dementia due to insufficient high-quality evidence. In summary, phosphatidylserine has a basis in scientific investigation for supporting cognitive function and dementia, but the evidence remains inconclusive and insufficient to warrant routine clinical use for this purpose.

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