Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion's mane mushroom (Hericium erinaceus) has garnered interest for its potential neuroprotective effects, particularly in the context of dementia and cognitive decline. The use of lion's mane for brain health is justified by emerging scientific evidence, primarily from preclinical studies and a small number of human clinical trials.

Preclinical research, including in vitro and animal studies, has demonstrated that lion's mane contains compounds such as hericenones and erinacines. These compounds can stimulate the synthesis of Nerve Growth Factor (NGF), a protein critical for the survival and function of neurons. In rodent models, administration of lion's mane extracts has been shown to improve memory and cognitive function, as well as reduce markers of neurodegeneration.

Human data is more limited but promising. A double-blind, placebo-controlled clinical trial published in 2009 (Mori et al., Phytotherapy Research) found that elderly Japanese individuals with mild cognitive impairment who consumed 3g/day of lion's mane mushroom powder for 16 weeks showed significantly improved cognitive scores compared to placebo. However, cognitive benefits declined after cessation of supplementation, suggesting effects may not be long-lasting without continued use. Most human studies to date are small, short-term, and of variable quality, with a need for larger and longer trials.

Traditional medicine systems in Asia have used lion's mane for "tonifying" the brain, but its modern application for dementia is primarily driven by scientific (rather than traditional) evidence, though this evidence remains preliminary. At present, lion's mane cannot be considered a proven treatment for dementia, but it is a promising area for continued research.

More about lion's mane
More about Dementia

Other ingredients used for Dementia

Other health conditions supported by lion's mane

Products containing lion's mane