Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones, a class of polyphenolic compounds found in various plants (notably in celery, parsley, and some medicinal herbs), have been studied for their potential neuroprotective effects. Preclinical studies suggest that flavones, such as apigenin and luteolin, may exert anti-inflammatory, antioxidant, and anti-amyloidogenic effects, which could theoretically be beneficial in neurodegenerative diseases like dementia and Alzheimer’s disease. These compounds have shown the ability to modulate signaling pathways involved in neuronal survival and reduce neuroinflammation in animal and cellular models.

However, the evidence in humans remains limited. While some small-scale clinical trials and epidemiological studies suggest that higher dietary intake of flavonoid-rich foods may be associated with a reduced risk of cognitive decline, there is no robust clinical evidence that isolated flavones or flavone supplements directly prevent or treat dementia. Most studies to date are observational, and controlled clinical trials are lacking or have produced inconclusive results. Thus, while the biological plausibility exists based on experimental data, clinical validation is weak, and the evidence base is rated low (2/5). More rigorous human research is needed before flavones can be recommended for the treatment or prevention of dementia.

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