Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a subclass of flavonoids, naturally occurring compounds found in many fruits, vegetables, and medicinal plants. Their use in supporting or treating dementia is primarily based on scientific exploration, particularly in preclinical (animal and in vitro) studies. Research has shown that flavones possess antioxidant, anti-inflammatory, and neuroprotective properties, which are relevant given the established role of oxidative stress and inflammation in the pathogenesis of dementia, including Alzheimer’s disease. Some flavones, such as apigenin and luteolin, have demonstrated the ability to modulate signaling pathways involved in neuronal survival, reduce amyloid-beta aggregation, and inhibit neuroinflammation in laboratory models. However, clinical evidence in humans is limited and mostly indirect. Some epidemiological studies suggest that diets rich in flavonoids (including flavones) are associated with a reduced risk of cognitive decline, but these studies do not isolate the effect of flavones specifically. Randomized controlled trials directly testing isolated flavones for dementia prevention or treatment are lacking. Thus, while there is a scientific rationale supported by preclinical data, human evidence remains insufficient, and flavones are not an established or approved treatment for dementia. Further research, particularly well-designed clinical trials, is needed to clarify their role and effectiveness in dementia care.

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