Evidence supporting the use of: Flavanols
For the health condition: Dementia
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Flavanols, a subclass of flavonoids found in foods such as cocoa, tea, apples, and berries, have been investigated for their potential neuroprotective effects, including their role in supporting cognitive function and possibly mitigating dementia risk. Some epidemiological studies suggest that higher dietary intake of flavanols is associated with better cognitive performance and a reduced risk of cognitive decline in older adults. Mechanistically, flavanols are thought to exert beneficial effects via antioxidant and anti-inflammatory pathways, improving cerebral blood flow and promoting synaptic plasticity.
However, the clinical evidence remains limited and somewhat inconsistent. A few randomized controlled trials (RCTs) have shown that flavanol-rich interventions, such as high-cocoa chocolate or cocoa supplements, may improve some aspects of cognitive function in older adults or those with mild cognitive impairment. For example, a 2023 RCT published in Alzheimer’s & Dementia found modest improvements in global cognition with daily cocoa flavanol supplementation. Nevertheless, these effects were small, and many studies are limited by short duration, small sample sizes, or methodological weaknesses.
In summary, there is emerging scientific interest and modest evidence supporting the potential cognitive benefits of flavanols, but the current data are insufficient to recommend them as a primary treatment or prevention strategy for dementia. More large-scale, long-term studies are needed to establish efficacy and clarify mechanisms.
Other ingredients used for Dementia
acetyl l-carnitinealgal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
astaxanthin
bilberry
blueberry
Chinese salvia root
citicoline
turmeric
DHA (docosahexaeonic acid)
fish oil
folate
ginger
ginkgo biloba
grape
green tea
huperzine A
l-carnosine
lion's mane
luteolin
marine lipid
melatonin
omega-3 fatty acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
quercetin
reishi mushroom
resveratrol
selenium
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
royal jelly
Anserine
Alpha glyceryl
Acetylcholine
Aniracetam
Butylphthalide
Beta-hydroxybutyrate
Basidiomycota
Brahmi
Bacopa
bacoside
Centrophenoxine
Curcuminoid
Convolvulus prostratus
Ketone Salts
Other health conditions supported by Flavanols
Alzheimer's DiseaseArteriosclerosis
Cancer (natural therapy for)
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Circulation (poor)
Circulation (to the brain)
Congestive Heart Failure
Dementia
Diabetes
Diabetic Retinopathy
Hypertension
Inflammation
Macular Degeneration
Memory and Brain Function
Metabolic Syndrome
Osteoporosis
Peripheral Neuropathy
Rheumatoid Arthritis
Strokes
Triglycerides (high)
Varicose Veins
Wrinkles