Evidence supporting the use of: DHA
For the health condition: Dementia
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
DHA (docosahexaenoic acid) is an omega-3 fatty acid found abundantly in the brain and is important for normal neurological development and function. The interest in DHA for supporting or treating dementia, particularly Alzheimer’s disease, arises from its role in neuronal membrane fluidity, synaptic function, and anti-inflammatory processes.
Several observational studies have suggested that higher dietary intake of DHA or higher blood DHA levels are associated with a reduced risk of cognitive decline and dementia. However, randomized controlled trials (RCTs) have produced mixed results. Some RCTs have failed to show significant cognitive benefits of DHA supplementation in people with established dementia, while others suggest a potential modest benefit in people with mild cognitive impairment or those at risk but not yet diagnosed with dementia.
Overall, current evidence does not strongly support DHA supplementation as an effective treatment for dementia, but there remains scientific interest in its preventive potential. Leading health organizations generally do not recommend DHA supplements as a primary treatment for dementia, though they often support a balanced diet rich in omega-3s for general brain health. The strength of evidence for DHA’s use in dementia is rated as low to moderate (2 out of 5), reflecting mostly observational data and a lack of consistent RCT evidence for therapeutic benefit.
Other ingredients used for Dementia
Acetyl L-carnitinealgal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
astaxanthin
bilberry
blueberry
Chinese salvia root
citicoline
turmeric
DHA (docosahexaenoic acid)
fish oil
folate
ginger
ginkgo biloba
grape
green tea
huperzine A
L-carnosine
lion's mane
luteolin
Marine lipid
Melatonin
omega-3 fatty acids
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
quercetin
reishi mushroom
resveratrol
selenium
Urolithin A
Vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
royal jelly
anserine
Alpha glyceryl
Acetylcholine
aniracetam
butylphthalide
beta-hydroxybutyrate
Basidiomycota
brahmi
Bacopa
bacoside
centrophenoxine
Curcuminoid
Convolvulus prostratus
folic acid
fo-ti
fatty acids
flavanols
flavones
galantamine
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
gastrodin
Homotaurine
Idebenone
ketone salts
Polygala
Palmitoylethanolamide (PEA)
Sulbutiamine
Shankhpushpi
Trehalose
Vincamine
Xanthophyll
Other health conditions supported by DHA
Alzheimer's DiseaseAnxiety
Arthritis
Asthma
Autism
Cancer (natural therapy for)
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Circulation (poor)
Congestive Heart Failure
Dementia
Depression
Diabetes
Fatty Liver Disease
Hypertension
Inflammation
Macular Degeneration
Memory and Brain Function
Menopause
Migraine
Multiple Sclerosis
Parkinson's Disease
Pregnancy (herbs and supplements for)
Rheumatoid Arthritis
Stress
Strokes
Triglycerides (high)