Five-Leaf Cassia (Senna alata), also known as "Ringworm Bush" or "Candle Bush," is traditionally used in various tropical regions, especially in Southeast Asia and Africa, to treat skin conditions such as fungal infections, including ringworm and dandruff. The leaves are commonly made into pastes or decoctions that are applied topically to the scalp to relieve flaking and itching associated with dandruff. The rationale in folk medicine is based on the plant’s perceived antifungal and antimicrobial properties.

Scientifically, Senna alata contains compounds like chrysophanic acid, which have demonstrated antifungal activity in vitro against dermatophytes, the fungi responsible for some skin disorders. However, robust clinical studies specifically evaluating the efficacy of Five-Leaf Cassia for dandruff (which is most commonly caused by the yeast Malassezia) are lacking. Most of the available evidence is anecdotal or based on traditional knowledge rather than modern clinical trials.

Thus, while there is a strong tradition supporting the use of Five-Leaf Cassia for dandruff, and some preliminary laboratory studies suggest antifungal properties, the evidence base is limited and not yet validated by high-quality clinical research. Its use for dandruff is therefore justified by tradition, with modest supporting evidence.