Bitter Grass, also known as Vernonia amygdalina or by similar names depending on the regional context, has been traditionally used in some cultures for a range of medicinal and topical applications, including the management of dandruff. The traditional usage is mostly based on anecdotal evidence and ethnobotanical reports, which suggest that preparations made from the leaves or extracts of Bitter Grass may help reduce scalp flakiness and irritation. These purported effects are often attributed to the plant's natural content of phytochemicals with antimicrobial or anti-inflammatory properties, such as saponins, flavonoids, and sesquiterpene lactones.

However, there is a notable lack of high-quality scientific research specifically assessing the efficacy of Bitter Grass for dandruff treatment. While some in vitro studies have demonstrated antimicrobial activity of Bitter Grass extracts against certain bacteria and fungi, these findings have not been robustly translated into clinical evidence for dandruff, which is commonly associated with Malassezia species. As such, the use of Bitter Grass for dandruff is primarily rooted in traditional practices rather than scientific validation. Until more rigorous studies are conducted, its efficacy for this purpose should be considered largely unproven from a modern evidence-based perspective.