Evidence supporting the use of: Quercetin
For the health condition: Cystic Fibrosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Quercetin, a plant-derived flavonoid, has attracted some scientific interest as a potential adjunct therapy for Cystic Fibrosis (CF). The rationale is primarily based on preclinical studies. CF is caused by mutations in the CFTR gene, resulting in defective chloride channel function. Some research suggests that quercetin can act as a "CFTR potentiator," meaning it may help improve the function of certain mutant CFTR proteins, notably the F508del mutation, which is the most common. Additionally, quercetin has demonstrated antioxidant and anti-inflammatory properties, which could theoretically help mitigate the chronic inflammation and oxidative stress seen in CF patients. However, most of the evidence comes from cell culture studies and animal models. Only a limited number of small pilot clinical trials have been conducted in humans, and these have yielded inconclusive results regarding efficacy and safety. There is currently insufficient high-quality clinical evidence to recommend quercetin as a standard therapy for CF, and its use should be considered experimental. Notably, quercetin is not a part of traditional medicine for CF, as CF is a relatively recently characterized genetic disease. In summary, while there is a scientific rationale and some preliminary data, robust clinical trials are lacking, so the evidence for quercetin’s use in CF is currently very weak.

More about quercetin
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Other ingredients used for Cystic Fibrosis

green tea
quercetin
resveratrol
vitamin C
vitamin D
Zinc