Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Prebiotics are non-digestible food components (typically fibers) that beneficially affect the host by selectively stimulating the growth and/or activity of beneficial gut bacteria. The rationale for their use in Crohn’s Disease (CD) is based on the hypothesis that modulation of gut microbiota may help control intestinal inflammation, as dysbiosis (an imbalance in gut microbial composition) is often observed in CD patients.

Several clinical studies have investigated various prebiotics (e.g., inulin, fructo-oligosaccharides) in Crohn's Disease. However, results are mixed and generally limited by small sample sizes and heterogeneity in prebiotic type and dosing. A 2012 Cochrane review concluded that there is insufficient evidence to support routine prebiotic supplementation for inducing or maintaining remission in Crohn’s Disease, though some studies noted modest improvements in inflammatory markers or symptoms. A more recent narrative review (2020) also reported that while prebiotics may improve gut microbial diversity, robust clinical benefits in CD have not been conclusively demonstrated.

In summary, prebiotic use in Crohn’s Disease is based on plausible biological rationale and limited scientific investigation, but current evidence is weak and does not support widespread use as a primary therapy. More large-scale, well-controlled trials are needed to clarify their efficacy and safety in this context.

More about Prebiotic (unspecified)
More about Crohn's Disease

Other ingredients used for Crohn's Disease

Other health conditions supported by Prebiotic (unspecified)

Products containing Prebiotic (unspecified)