Evidence supporting the use of: Lactobacillus (various species)
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Lactobacillus species, a group of probiotic bacteria, have been explored for their role in managing Crohn's Disease (CD), a type of inflammatory bowel disease. The rationale stems from the observation that alterations in gut microbiota are associated with CD, and probiotics could theoretically help restore microbial balance and modulate immune responses. However, scientific validation for the use of Lactobacillus specifically in Crohn's Disease is limited and inconsistent.

Several randomized controlled trials and meta-analyses have examined the efficacy of Lactobacillus-containing probiotics in inducing or maintaining remission in CD patients. Most studies — including clinical trials using Lactobacillus rhamnosus GG and mixtures such as VSL#3 (which contains multiple probiotic strains including Lactobacillus species) — have not shown significant benefit over placebo in reducing relapse rates, improving symptoms, or maintaining remission. For example, a 2008 Cochrane review and subsequent systematic reviews have concluded that there is insufficient evidence to recommend Lactobacillus-based probiotics for the treatment or maintenance of remission in Crohn's Disease.

While the theoretical basis and some preclinical studies suggest a potential for probiotics in modulating inflammation, current clinical evidence does not support a strong role for Lactobacillus in Crohn's Disease management. Thus, its use is best characterized as scientifically investigated but weakly supported, meriting a low evidence rating.

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