Evidence supporting the use of: Lactiplantibacillus plantarum
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) is a probiotic bacterium that has been studied for its potential to support gastrointestinal health, including in inflammatory bowel diseases like Crohn’s Disease. The scientific justification for its use in Crohn’s Disease is limited but present, primarily based on small clinical trials, animal studies, and the known immunomodulatory effects of certain probiotic strains.

Some research has shown that L. plantarum can help modulate gut microbiota composition, enhance the mucosal barrier, and reduce intestinal inflammation in experimental models. In vitro and animal studies suggest that this strain may decrease the production of pro-inflammatory cytokines and reinforce the intestinal epithelial barrier, mechanisms relevant to Crohn’s pathology.

However, human studies are scarce. A handful of small clinical trials and case reports have investigated the effects of L. plantarum (often as part of multi-strain probiotic mixtures) in patients with Crohn’s Disease. Results are mixed: while some patients report symptom improvement and reduced inflammation, larger, well-controlled clinical trials are lacking. Systematic reviews and guidelines from major gastroenterology societies generally regard the evidence as insufficient to recommend routine probiotic use for Crohn’s Disease, though they acknowledge a favorable safety profile.

In summary, the use of Lactiplantibacillus plantarum for Crohn’s Disease is justified by preliminary scientific evidence, but current support is weak (2/5), and further high-quality studies are necessary to confirm its clinical benefits.

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