Evidence supporting the use of: Cannabis
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabis has been explored as a potential treatment for Crohn's Disease, primarily due to its anti-inflammatory and immunomodulatory properties. The endocannabinoid system, which includes cannabinoid receptors in the gut, suggests a plausible mechanism for symptom relief. Several small clinical studies and patient surveys have reported subjective improvement in symptoms such as pain, appetite, and quality of life in Crohn’s patients using cannabis. For example, a randomized controlled trial published in Clinical Gastroenterology and Hepatology (Naftali et al., 2013) found that inhaled cannabis led to significant symptom improvement in a subset of patients with Crohn’s Disease, although it did not significantly induce remission. Other observational studies and case reports support improvement in symptom management, though not necessarily changes in underlying disease activity.

However, the overall quality of evidence is low. Most studies are small, short-term, and have methodological limitations. Major gastrointestinal societies do not currently recommend cannabis as a primary therapy for Crohn’s Disease due to insufficient evidence and potential side effects. Thus, while there is some scientific investigation and many patient anecdotes, robust clinical validation is lacking, justifying a modest evidence rating.

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Products containing Cannabis

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