Evidence supporting the use of: Cannabidiol
For the health condition: Crohn's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabidiol (CBD) is a non-psychoactive compound derived from the cannabis plant. Its use in supporting or treating Crohn's Disease is primarily justified by emerging scientific interest, but robust evidence is still limited. Preclinical studies suggest that CBD may possess anti-inflammatory and immunomodulatory effects, which are relevant to the inflammatory processes in Crohn's Disease. However, human clinical evidence is currently sparse and inconclusive.

Several small-scale clinical trials have investigated the effects of CBD or cannabis extracts in people with Crohn's Disease. While some patient-reported improvements in symptoms such as pain and quality of life, most studies have failed to demonstrate significant reductions in objective markers of disease activity or inflammation (such as endoscopic scores or C-reactive protein levels). For example, a randomized, double-blind, placebo-controlled trial published in 2017 in Gut found that CBD-rich cannabis did not induce remission but did improve quality of life. Systematic reviews highlight the need for larger, well-controlled studies.

Guidelines from organizations such as the Crohn's & Colitis Foundation and the American Gastroenterological Association do not currently recommend CBD as a treatment for Crohn’s Disease due to insufficient high-quality evidence. In summary, while there is scientific rationale and preliminary investigation, the current level of evidence to support CBD for Crohn's Disease is weak (rated 2/5), and its use should be considered experimental.

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