Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flavonoid glycosides, naturally occurring compounds found in many plants, have traditionally been used in herbal medicine to alleviate symptoms associated with menstrual cramps (dysmenorrhea). Plants rich in flavonoid glycosides, such as chamomile (Matricaria chamomilla), have a long history of use in European and Middle Eastern folk medicine for their purported antispasmodic and anti-inflammatory effects, which are believed to help relieve uterine muscle cramps. The rationale is that these compounds may inhibit the synthesis of prostaglandins, substances involved in pain and inflammation during menstruation, and may also promote muscle relaxation. However, scientific research specifically examining flavonoid glycosides for menstrual cramps is limited. Most evidence is either anecdotal or extrapolated from general studies on the anti-inflammatory and muscle-relaxant properties of flavonoids. Some small studies on herbal preparations containing flavonoid glycosides (such as chamomile tea or extracts) have reported reduced pain severity in women with menstrual cramps, but these studies often use whole plant extracts rather than isolated flavonoid glycosides, making it difficult to attribute effects to these compounds alone. Overall, the use of flavonoid glycosides for menstrual cramps is primarily supported by traditional use and limited preliminary research, but robust clinical evidence is lacking.

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