Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium citrate malate is used to support or treat cramps and spasms primarily based on scientific validation, though the quality and strength of evidence is moderate. Magnesium plays an essential physiological role in muscle contraction and relaxation. Deficiency of magnesium has been linked to muscle cramps, particularly in populations at risk, such as pregnant women, older adults, and athletes. Several randomized controlled trials have evaluated magnesium supplementation (various salts, including citrate and malate) for muscle cramps, with mixed but generally positive results for those with suboptimal magnesium status.

For example, a 2012 Cochrane review found limited but suggestive evidence that magnesium supplementation may reduce the frequency and severity of cramps in pregnant women, though results in the general population were less clear. Magnesium citrate and malate are organic forms with relatively high bioavailability, making them suitable choices for supplementation. However, not all studies show clear benefits, especially in individuals with normal magnesium levels. While magnesium is routinely recommended in clinical settings for muscle cramps when a deficiency is suspected, routine supplementation for all cases of cramps or spasms is not broadly supported by high-quality evidence.

In summary, magnesium citrate malate is justified for cramps and spasms when deficiency is likely or confirmed, with moderate scientific support (evidence rating: 3/5). More research is needed to clarify its effectiveness in the general population without overt magnesium deficiency.

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