Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Jimson weed (Datura stramonium) has a long history of traditional use for a variety of ailments, including the relief of cramps and spasms. Historically, Native American and other traditional medical systems used preparations from the leaves and seeds as antispasmodic agents, particularly for asthma, muscle cramps, and gastrointestinal spasms. The primary pharmacologically active compounds in Jimson weed are tropane alkaloids, such as atropine, scopolamine, and hyoscyamine. These compounds are known to have anticholinergic effects, which can relax smooth muscle and reduce involuntary muscle contractions, thus providing a plausible mechanism for their traditional use in treating cramps and spasms.

Despite this traditional use and a reasonable pharmacological basis, scientific validation through controlled clinical trials is lacking due to the high toxicity and narrow therapeutic window of Jimson weed alkaloids. Adverse effects—including delirium, hallucinations, and potentially fatal poisoning—make medical use highly risky and not recommended in modern clinical practice. Therefore, while there is some traditional and pharmacological rationale for its use as an antispasmodic, the overall evidence base is weak and largely historical, and its use is considered unsafe today.

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